Research team led by Professor Ling Qin has published a series of findings in high impact journals. Published in Biomaterials, they have reported the promotive effect of magnesium on the enrichment of calcitonin gene-related peptide (CGRP) to efficiently improve the healing of anterior cruciate ligament (ACL) reconstruction in rabbits . In yet another paper in Biomaterials, they have summarized the progress, challenges, and perspectives on the development of biomaterials for facilitating the ACL reconstruction healing .
Collaborating with overseas Universities and Peking University, in rat calvaria defect model, they found that addition of sodium in magnesium-based mesh could stimulate both osteogenesis and angiogenesis in situ . Inspired by these works, they have also investigated the effects of magnesium supplemented as ions form. Oral intake of magnesium chloride could synergize with simvastatin to attenuate obesity-induced bone loss in mice . Intra-articular injection of reagents containing magnesium chloride and vitamin C promisingly reduced osteophyte formation and synovitis in the osteoarthritic model of mice .
Several patents have been generated from these findings. Extensive translational studies are still ongoing, under the supports from RGC grants (Areas of Excellence, Theme-based Research Scheme, Collaborative Research Fund, General Research Fund), ITF, and HMRF. Congratulations to Prof. Ling Qin and his team!
Please refer to the following papers for more details:
 J. Wang, J. Xu (equal-first), X. Wang, L. Sheng, L. Zheng, B. Song, G. Wu, R. Zhang, H. Yao, N. Zheng, M.T. Yun Ong, P.S. Yung, L. Qin*. Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction, Biomaterials 268 (2021) 120576. [IF: 10.317]
 X. He, Y. Li, J. Guo, J. Xu, H. Zu, L. Huang, M. Tim-Yun Ong, P. Shu-Hang Yung, L. Qin*. Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models, Biomaterials 269 (2021) 120625. [IF: 10.317]
 Y. Liu, H. Li (equal-first), J. Xu (equal-first), J. TerBush, W. Li, M. Setty, S. Guan, T.D. Nguyen, L. Qin*, Y. Zheng*. Biodegradable metal-derived magnesium and sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation, Chemical Engineering Journal 410 (2021). [IF: 10.652]
 B. Dai, X. Li (equal-first), J. Xu*, Y. Zhu, L. Huang, W. Tong, H. Yao, D.H.K. Chow, L. Qin*. Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss, Bioactive Materials 6(8) (2021) 2511-2522. [IF: 8.724]
 H. Yao, J. Xu, J. Wang, Y. Zhang, N. Zheng, J. Yue, J. Mi, L. Zheng, B. Dai, W. Huang, S. Yung, P. Hu, Y. Ruan, Q. Xue, K. Ho*, L. Qin*. Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice, Bioactive Materials 6(5) (2021) 1341-1352. [IF: 8.724]