Publications

2016  

miRNA-29b improves bone healing in mouse fracture model.  Lee WYW Lee, Li N, Lin SE, Wang B, Lan HY, Li G.  Molecular and Cellular Endocrinology, 2016; in press (IF=4.45).

Meng FB, Xu LL, Huang S, Liu Y, Hou YH, Wang KX, Jiang XH, Li G. Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2. Cell & Tissue Research, 2016; in press (IF=3.56).

Yin Zi, Guo J, Wu TY, Chen X, Xu LL, Lin SE, Sun YX, Chan KM, Ouyang HW, Li G. Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo. Stem Cells Translational Medicine, 2016, in press. (IF=5.71)

Lu YF, Li G, Chan KM, Zhang JF. Tendon differentiation and noncoding RNA: from bench to bedside. Experimental Cell Research, 2016; in press (IF=3.25).

Wei KC, Zhu ML, Sun YX, Xu JB, Feng Q, Lin SE, Wu TY, Xu J, Tian F, Li G, Bian LM.  Robust biopolymeric supramolecular “Host−Guest Macromer” hydrogels reinforced by in situ formed multivalent nanoclusters for cartilage regeneration. Macromolecules, 2016; in press (IF=5.8).

Liang WC, Fu WM, Sun YX, Xu LL, Wang YB, Chan KM, Li G, Waye MM, Zhang JF. Antagonistic roles of lincRNA H19 and miR-675 in the regulation of osteoblast differentiation. Scientific Reports, 2016, in press (IF=5.58).

Fu WM, Lu YF, Hu BG, Liang WC, Zhu X, Yang HD, Li G, Zhang JF. Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling. Oncotarget, 2016; in press (IF=6.37).

Li J, Lee YW, Wu T, Xu J, Zhang K, Li G, Bian L. Multifunctional quantum dot nanoparticles for effective differentiation and long-term tracking of human mesenchymal stem cells in vitro and in vivo. Advanced Healthcare Materials,2016 May; 5(9):1049-57. (IF: 5.79)

Chen YF, Lin S, Sun YX, Pan XH, Xiao LB, Zou LY, Ho KW, Li G. Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis. Journal of Orthopaedic Translation, 2016; 6: 27-33.

Deng YJ, Li P, Li G, Qin L, Mak KK. Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and bone repair. Cell Reports, 2016 March 8; 14(9): 2224-2237 (IF=7.2).

Guo J, Chan KM, Zhang JF, Li G.  Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Experimental Cell Research, 2016; 341:1-7. (IF=3.25).

Liu Y, Rui YF, Cheng TY, Huang S, Xu LL, Meng FB, Lee W, Ke HZ, Li G.  Effects of sclerostin antibody on the healing of femoral fractures in ovariectomised rats. Calcified Tissue International, 2016; 98(3): 263-274.  (IF: 2.50)

Zhu M, Lin S, Feng Q, Sun Y, Li G, Bian L. Hydrogels functionalized with N-cadherin mimetic peptide enhance the osteogenesis of hMSCs by emulating the oteogenic niche. Biomaterials, 2016; 77:44-52. (IF: 8.7)

 
2015  
 

Li G, Lin Sien. Stem cells, tissue regeneration and aging. Journal of Guangdong Medical College, 2015; 33(5): 503-505.

Guo J, Zhang J, Li G, Chan KM.  A mini-review: microRNA in tendon injuries. J Stem Cell Res & Therapy; 2015, 5:9 (IF=2.2)

Zhu M, Lin S, Feng Q, Sun Y, Li G, Bian L. Hydrogels functionalized with N-cadherin mimetic peptide enhance the osteogenesis of hMSCs by emulating the oteogenic niche. Biomaterials, 2015 Nov 2; 77:44-52. (IF: 8.7)

Huang S, Xu LL, Zhang YF, Sun YX, Li G. Systemic and local administration of allogeneic bone marrow derived mesenchymal stem cells promotes fracture healing in rats. Cell Transplantation, 2015; 24: 2643–2655. (IF=4.42)

Lau CP, Wong KC, Huang L, Li G, Tsui SK, Kumta SM. A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. Connective Tissue Research, 2015 Nov; 56(6):493-503. (IF=1.61).

Huang S, Xu LL, Sun YX, Zhang YF, Li G. The fate of systemically administrated allogeneic mesenchymal stem cells (MSCs) in mouse femoral fracture healing. Stem Cell Research and Therapy, 2015, 6: 206 (DOI: 10.1186/s13287-015-0198-7) (IF=3.37)

Yu LM, Huang JP, Wang J, Cui L, Sun YX, Chen LY, Su YJ, Lin S, Li G. Antler collagen/chitosan scaffolds improve critical calvarial defect healing in rats. Journal of Biomaterials and Tissue Engineering, 2015; 5:1-6. (IF: 2.07)

Fu WM, Zhu X, Wang WM, Lu YF, Hu BG, Wang H, Liang WC, Wang SS, Ko CH, Waye MMY, Kung HF, Li G, Zhang JF. Hotair mediates hepatocarcinogenesis through suppressing MiRNA-218 expression and activating P14 and P16 signaling. Journal of Hepatology; 2015 Oct; 63(4): 886-95. (IF: 9.6).

Chen YF, Sun YX, Pan XH, Ho KW, Li G.  Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change. Osteoarthritis and Cartilage; 2015; 23 (10): 1728-1735. (IF:4.6)

Thomas NP, Li P, Fleming BC, Chen Q, Wei X, Xiao-Hua P, Li G, Wei L.  Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100.  Journal Orthopedic Research, 2015; 33(7):1071-8. (IF: 2.97)

Rui YF, Xu LL, Chen R, Zhang T, Lin S, Hou YH, Liu Y, Meng FB, Liu ZQ, Ni M, Tsang KZ, Yang FY, Wang C, Chan HC, Jiang XH, Li G. Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Scientific Reports, 2015; 5:11056(1-15). (IF: 5.08)

Liu S, Rui YF, Li G, Wang C. Alterations of tendons in diabetes mellitus: what are the current findings? International Orthopaedics, publication online 6 May 2015, DOI 10.1007/s00264-015-2775-x (IF: 2.02)

Luo KW, Ko CH, Yue GG, Gao S, Lee JK, Li G, Fung KP, Leung PC, Evdokiou A, Lau CB. The combined use of Camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model. Journal of Cancer Research and Clinical Oncology, 2015;141(6):1025-36. doi: 10.1007/s00432-014-1882-1. (IF=3.08)

Luo KW, Yue GG, Ko CH, Gao S, Lee JK, Li G, Fung KP, Leung PC, Lau CB. The combined use of Camellia sinensis and metronomic zoledronate in 4T1 mouse carcinoma against tumor growth and metastasis. Oncology Reports, 2015 Jul; 34(1):477-87. doi: 10.3892/or.2015.4001. (IF=2.30)

Chen X, Gu S, Chen BF, Shen WL, Yin Z, Xu GW, Hu JJ, Zhu T, Li G, Wan C, Ouyang HW, Lee TL, Chan WY.  Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 2015; 53: 239-250. (IF: 8.3)

Lin SE, Huang JP, Fu ZW, Liang YL, Wu HY, Xu LL, Sun YX, Lee WYW, Wu T, Qin L, Cui L, Li G.  The effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats. Calcified Tissue International, 2015 Jun; 96(6):541-51. doi: 10.1007/s00223-015-9975-7 (IF: 2.50

Sun YX, Xu LL, Huang S, Liu Y, Hou YH, Chan KM, Pan XH, Li G. Mir-21 overexpressing mesenchymal stem cells accelerate fracture healing in a rat closed femur fracture model. BioMed Research International, 2015:412327. doi:10.1155/2015/412327 (IF: 2.7).

Wang KX, Xu LL, Rui YF, Huang S, Lin SE, Xiong JH, Li YH, Lee WYW, Li G.  The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells. PLoS One, 2015; 10(3): e0120593 (IF: 3.53)

Huang B, Li G, Jiang XH. Fate determination in mesenchymal stem cells: A perspective from histone modifying enzymes. Stem Cell Research & Therapy, 2015; 6(1): 35. (IF=4.63)

Wu CL, Liu FL, Li PD, Zhao GF, Lan SW, Jiang WY, Meng XW, Tian LX, Li G, Li YL, Liu JY. Engineered hair follicle mesenchymal stem cells overexpressing controlled-release insulin reverse hyperglycemia in mice with type l diabetes. Cell Transplantation, 2015; 24: 891-907. (DOI: 10.3727/096368914X681919) (IF: 4.42)\

Nadeem D, Smith CA, Dalby MJ, Meek RMD, Lin S, Li G, Su B. Three-dimensional CaP/gelatin lattice scaffolds with integrated osteoinductive surface topographies for bone tissue engineering. Biofabrication, 2015; 7(1):015005. (doi:10.1088/1758-5090/7/1/015005) (IF=4.3)

Xu LL, Huang S, Hou YH, Liu Y, Ni M, Meng FB, Wang KX, Rui YF, Jiang XH, Li G. Sox11-modified mesenchymal stem cells (MSCs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of MSCs. FASEB Journal, 2015; 29(4):1143-52. doi: 10.1096/fj.14-254169. (IF=5.48)

Xu LL, Liu Y, Hou YH, Wang KX, Wong YM, Lin SE, Li G. U0126 promotes osteogenesis of rat bone marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. Cell & Tissue Research, 2015; 359(2): 537-545. (IF: 3.33).

Huang S, Xu LL, Sun YX, Wu TY, Wang KX, Li G. An improved protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Journal of Orthopaedic Translation; 2015; 3: 26-33.

2014  
 

Zhao J, Tang H, Wang J, Li G.  Local treatment of osteoporosis with alendronate-loaded calcium phosphate cement. Chinese Medical Journal (English), 2014; 127(22):3906-14. (IF: 1.02).

Liu J, Nie H, Xu Z, Niu X, Guo S, Yin J, Guo F, Li G, Wang Y, Zhang C. The Effect of 3D nanofibrous scaffolds on the chondrogenesis of induced pluripotent stem cells and their application in restoration of cartilage defects. PLoS One, 2014; 9(11): e111566. (IF: 3.53)

Wei FY, Leung KS, Li G, Qin J, Chow SK, Huang S, Sun MH, Qin L, Cheung WH. Low Intensity Pulsed Ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS One, 2014; 9(9): e106722. (IF: 3.53)

Lin SE, Huang JP, Zheng L, Liu YZ, Fu ZW, Xu BL, Wu T, Qin L, Li G, Cui L. Glucocorticoid-induced osteoporosis in growing rats. Calcified Tissue International, 2014; 95:362-373. (IF: 2.50)

Li N, Lee YW, Lin SE, Ni M, Zhang T, Huang XR, Lan HY, Li G.  Partial loss of Smad7 function impairs osteogenesis and enhances osteoclastogenesis in mice. Bone, 2014; 67: 46-55.  (IF: 3.82).

Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB.  In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine, 2014; 21 (8-9): 1078-87. doi: 10.1016/j.phymed.2014.04.020. (IF: 3.24)

Luo KW, Ko CH, Yue GG, Lee JK, Li KK, Lee M, Li G, Fung KP, Leung PC, Lau CB. Green tea (Camellia sinensis) extract inhibits both the metastasis and osteolytic components of mammary cancer 4T1 lesions in mice. The Journal of Nutritional Biochemistry, 2014; 25(4):395-403. doi: 10.1016/j.jnutbio.2013.11.013. (IF: 4.59)

Xu D, Xu L, Zhou C, Lee WY, Wu T, Cui L, Li G.  Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway. International Journal of Biochemistry and Cell Biology, 2014; 51: 1-9. doi: 10.1016/j.biocel.2014.03.005. (IF: 4.24)

Wu TY, Liu Y, Wang B, Li G. The roles of mesenchymal stem cells in tissue repair and disease modification. Current Stem Cell Research and Therapy, 2014; 9: 424-431. (IF: 2.96)

Meng FB, Rui YF, Xu LL, Wan C, Jiang XH, Li G. Aqp1 enhances migration of bone marrow mesenchymal stem cells through regulation of FAK and β-catenin. Stem Cells and Development, 2014; 23(1):66-75. doi: 10.1089/scd.2013.0185. (IF: 4.67)

Xu LL, Li G. Circulating mesenchymal stem cells and their clinical implications. Journal of Orthopaedic Translation, 2014; 2: 1-7. (http://dx.doi.org/10.1016/j.jot.2013.11.002)

Lin LW, Wang H, Ni M, Rui YF, Cheng TY, Cheng CK, Pan XH, Li G, Lin CJ. Enhanced osteo-integration of medical titanium implant with surface modifications in micro-nano scale structures. Journal of Orthopaedic Translation, 2014; 2: 35-42.
2013  
 

Yang Y, Su Y, Wang D, Chen Y, Li G, Sun X, Cui L. Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt/FoxO3a Signaling.  Oxidative Medicine and Cellular Longevity, 2013; 2013:351895. doi: 10.1155/2013/351895 (IF: 3.39)

Tsang WP, Shu YL, Kwok PL, Zhang FJ, Lee KKH, Tang MK, Li G, Chan KM, Chan WY, Wan C. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS One, 2013; 8(10): 3.730. (IF: 3.73)

Lan X, Zhang LH, *TP, Xia HT, Li G, Peng AM, Han YL, Yuan BT,  Xu, WP.  S-osteotomy with lengthening and then nailing compared with traditional Ilizarov method. International Orthopaedics, 2013; 37(10):1995-2000. (IF: 2.32)

Lee WYW, Zhang T, Lau CPY, Wang CC, Chan KM, Li G.  Immortalized human fetal bone marrow-derived mesenchymal stem cell expressing anti-tumor suicide gene for anti-tumor therapy in vitro and in vivoCytotherapy, 2013; 15:1484-1497. (IF: 3.96)

李剛, 夏和桃。 應力與骨組織再生的生物學和生物力學基礎。 中華創傷骨科雜誌, 2013;15(10): 871-875.

Luo KW, Ko CH, Yue GG, Lee MY, Siu WS, Lee JK, Shum WT, Fung KP, Leung PC, Li G, Evdokiou A, Lau CB.  Anti-tumor and anti-osteolysis effects of the metronomic use of zoledronic acid in primary and metastatic breast cancer mouse models. Cancer Letters, 2013; 339 (1): 42-8. (IF: 4.86)

Zhang T, Lee YW, Rui YF, Cheng TY, Xh Jiang, Li G. Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Research & Therapy, 2013; 4:70 doi:10.1186/scrt221. (IF: 3.21)

Chai W, Ni M, Rui YF, Zhang KY, Zhang Q, Xu LL, Chan KM, Li G, Wang Y. Effect of growth and differentiation factor 6 on the tenogenic differentiation of bone marrow-derived mesenchymal stem cells. Chinese Medical Journal (Engl), 2013 Apr; 126(8):1509-16. (IF: 0.90)

Zhao J, Yang C, Su C, Yu M, Zhang X, Hang S, Li G, Yu M, Li X. Reconstruction of orbital defects by implantation of antigen-free bovine cancellous bone scaffold combined with bone marrow mesenchymal stem cells in rats. Graefe's Archive for Clinical and Experimental Ophthalmology, 2013; 251:1325–1333. (IF: 2.17)

Cui L, Cheng H, Song C, Li CY, Simonet WS, Ke HZ, Li G. Time-dependent effects of Sclerostin antibody on a mouse fracture healing model. Journal of Musculoskeletal and Neuronal Interactions, 2013; 13(2):178-184. (IF: 2.0)

Meng FB, Liu XY, Li HT, Pang XN and Li G. Regulation of blood glucose by administration of allogenic bone marrow derived mesenchymal stem cells into diabetic rats through modulating regeneration of both α and β islet cells. Journal of Diabetes Research & Clinical Metabolism, 2013; 2:1 (DOI: http://dx.doi.org/10.7243/2050-0866-2-7).

Zhang XB, Meng XM, Baylink D, Neises A, Kiroyan J, Su RJ, Kimberly P, Gridley D, Wang J, William KH, Lee W, Li G.  Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor. Cell Research, 2013; 23(5):658-72. (IF:10.53).

Ni M, Rui YF, Tan Q, Liu Y, Xu LL, Chan KM, Wang Y, Li G.  Engineered scaffold-free tendon tissue produced by tendon-derived stem cells. Biomaterials, 2013; 34: 2024-2037. (IF: 8.3).

Xu LL, Meng FB, Ni M, Lee YW, Li G. N-cadherin regulates osteogenesis and migration of bone marrow-derived mesenchymal stem cells. Molecular Biology Report, 2013; 40(3):2533-2539. (IF:2.93)

Cheung WH, Chin WH, Wei FY, Li G, Leung KS. Applications of exogenous mesenchymal stem cells and low intensity pulsed ultrasound enhance fracture healing in rat model.  Ultrasound in Medicine and Biology, 2013 Jan; 39(1):117-25. (IF: 2.49)

2012  
 

Wang CC, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, Cheng JTY, Li G, He YX, Qin L, Chan TH. Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice.  Angiogenesis, 2012; 16:59–69. (IF:6.06)

Yao D, Xie XH, Wang XL, Wan C, Lee YW, Pei DQ, Wang YX, Li G, Qin L*. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesisv - An in vitro efficacy study.  PLoS One, 2012; 7(8): e41264. (IF: 3.73)

Shen B, Chu ES, Zhao G, Man K, Wu CW, Cheng JT, Li G, Nie Y, Lo CM, Teoh N, Farrell GC, Sung JJ, Yu J.  PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. British Journal of Cancer, 2012 Apr 24; 106(9):1486-94. (IF: 4.83)

Fan QM, Yue B, Bian ZY, Xu WT, Tu B, Dai KR, Li G, Tang TT.  The CREB–Smad6–Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone. Journal of Pathology, 2012; 228(1):45-55 (IF: 7.25).

Tang JQ, Zhang LY, She XL, Zhou GQ, Yu FL, Xiang JJ, Li G.  Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility and metastasis in vitro and in vivo.  Cancer Investigation, 2012 Jun; 30(5): 380-9. (IF: 2.11)

Ma LL, Meng FB, Shi P, Li G, Pang XN. Quantity and proliferation rate of mesenchymal stem cells in human cord blood during gestation. Cell Biology International, 2012; 36:415-418. (IF: 1.75)

Xu LL, Song C, Ni M, Meng, FB, Xie HQ, Li G.  Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR-a-induced ß-catenin degradation. The International Journal of Biochemistry & Cell Biology, 2012; 44:612-619. (IF: 4.96)

Ni M, Cheng TY, Rui YF, Chan KM, Kuhstoss S, Ma YF, Sato M, Wang, Y, Li G.  Dose-dependent enhancement of spinal fusion in rats with Teriparatide [PTH(1-34)].  Spine, 2012; 37(15):1275-1282. (IF: 2.79)

He YX, Pan XH, Tang T, Guo BS, Zheng LZ, Xie XH, Wang XL, Lee KM, Li G, Cao YP, Wei L, Chen Y, Yang ZL, Hung LK, Qin L, Zhang G. Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporosis International, 2012; 23(1):377-89.(IF:4.86)

Ni M, Lui PP, Rui YF, Lee YW, Lee YW, Tan Q, Wong YM, Kong SK, Lau PM, Li G, Chan KM. Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model. Journal of Orthopaedic Research, 2012; 30 (4): 613-9 (IF: 2.98)

Luo ZH, Zhang LY, Li Z, Li XY, Li G, Yu HB, Jiang C, Dai YF, Guo XF, Xiang JJ, Li GY.  An in silico analysis of dynamic changes in microRNA expression profiles in stepwise development of nasopharyngeal carcinoma. BMC Medical Genomics, 2012; 5:3. (IF: 3.77)

Green DW, Li G, Milthorpe B, Ben-Nissan B. Mesenchymal stem cells coated with biomaterials in regenerative medicine.  Materials Today, 2012; 5(1-2): 626-632. (IF: 6.26)

Zhang G, Guo B, Wu H, Tang T, Zhang B, Zheng L, He Y, Yang Z, Pan X, Chow H, To K, Li Y, Li D, Wang X, Wang Y, Lee K, Hou Z, Dong N, Li G, Leung K, Hung L, He F, Zhang L, Qin L.  A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine, 2012; 18(2): 307-14 (IF: 25.43).

2011  
 

Ni M, Tang PF, Wang Y, Li G.  Experimental study on promoting bone consolidation by using platelet-rich plasma and decalcified bone matrix during distraction osteogenesis.  Chinese Journal of Reparative and Reconstructive Surgery, 2011; 25(6):661-7.

Tang JQ, Luo ZH, Zhou GQ, Song C,Yu FL, Xiang JJ, Li G.  Cis-regulatory functions of overlapping HIF-1alpha/E-box/AP-1-like sequences of CD164. BMC Molecular Biology, 2011; 12:44. (IF: 3.19)

Ni M, Rui YF, KM Chan, Wang Y, Li G.  Effect of growth differentiation factor 7 on tenogenic differentiation of bone marrow mesenchymal stem cells of rat in vitro.  Chinese Journal of Reparative and Reconstructive Surgery, 2011; 25(9):1103-9.

Ni M, Li G, Tang PF, Chan KM, Wang Y.  rhBMP-2 not Alendronate combined with HA-TCP biomaterial and distraction osteogenesis enhance bone formation.  Archives of Orthopaedic and Trauma Surgery, 2011; 131:1469–1476 (IF: 1.2)

Wang Y, Huang P, Tang PF, Chan KM, Li G. Alendronate (ALN) combined with osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats. Journal of Orthopaedic Surgery and Research, 2011: 6:34.

Hui FF, Chan WC, Yeung HY, Lee KM, Qin L, Li G, Hu YY, Cheng JCY. Low intensity pulsed ultrasound enhances posterior spinal fusion implanted with mesenchymal stem cells-calcium phosphate composite without bone grafting. Spine, 2011; 36 (13): 1010-6. (IF: 2.79)

Ominsky MS, Li CY, Li XD, Tan HL, Lee E, Barrero M, Asuncion FJ, Dwyer D, Han CY, Vlasseros F,  Samadfam R, Jolette J, Smith SY, Stolina M, Lacey DL, Simonet WS, Paszty C, Li G, Ke HZ. Inhibition of Sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones.  Journal of Bone and Mineral Research, 2011, 26 (5):1012–1021. (IF: 6.04).

Song C, Li G. CXCR4 and MMP-2 are involved in mesenchymal stem cells homing and engraftment to the tumors.  Cytotherapy, 2011; 13(5): 549-61. (IF: 3.55)

Song C, Xiang J, Tang JQ, Hirst D, Zhou JW, Chan KM, Li G. Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for anti-tumor therapy.  Human Gene Therapy , 2011; 22(4):439-49. (IF: 4.20)

Lu H, Hu J, Qin L, Chan KM, Li G, Li KH. Area, length and mineralization content of new bone at bone–tendon junction predict its repair quality. Journal of Orthopaedic Research, 2011; 29(5):672-7. (IF: 3.11)

He YX, Zhang G, Pan XH, Liu Z, Zheng LZ, Chan CW, Lee KM, Cao YP, Li G, Wei L, Hung LK, Leung KS, Qin L. Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model. Bone, 2011 (48):1388–1400. (IF: 4.20)

Rui YF, Lui PPY, Chan LS, Chan KM, Fu SC, Li G. Does erroneous differentiation of tendon-derived stem cells (TDSCs) contribute to the pathogenesis of calcifying tendinopathy? Chinese Medical Journal (Engl), 2011;124:606-610. (IF: 0.95)

2010  
 

Tang H, Zhao JD, Li Y, Chen H, Jia P, Chan KM, Li G.  The efficacy of percutaneous kyphoplasty (PKP) in treating osteoporotic multi-thoracolumbar vertebral compression fractures. Orthopaedics, 2010; 33 (12): 885-90. (IF: 1.91)

Bian ZY, Fan QM, Li G, Xu WT, Tang TT. Human mesenchymal stem cells promote growth of osteosarcoma: the involvement of interleukin-6 in the interaction between hMSCs and Saos-2 cells.  Cancer Science, 2010; 101(12): 2554-60. (IF: 3.77)

Rui YF, Lui PP, Li G, Fu SC, Lee YW, Chan KM. Isolation and characterization of multipotent rat tendon-derived stem cells.  Tissue Engineering Part A 2010; 16(5):1549-58. (IF:5.44)

Weber AJ, Li G, Kalak R, Street J, Buttgereit F, Dunstan CR, Seibel MJ, Zhou H.  Osteoblast-targeted disruption of glucocorticoid signaling does not delay intramembranous bone healing.  Steroids , 2010; 75(3): 282-285. (IF: 2.90)

Yang Z, Shi Y, Wei X, He J, Yang S, Dickson G, Tang J, Xiang J, Song C, Li G.  Fabrication and repair of cartilage defects with a novel acellular cartilage matrix scaffold. Tissue Engineering Part C Methods , 2010; 16(5):865-76. (IF: 5.44)

2009  
 

Xiang J, Tang JQ, Song C, Zhao L, Yang ZQ, Hirst DG, Li G.  Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma. Cytotherapy, 2009; 26:1-11.  (IF: 3.55)

Kalak R, Zhou H, Street J, Day RE, Modzelewski JRK, Spies CM, Liu PY, Li G, Dunstan CR, Seibel MJ.  Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 2009; 45(1):61-7. (IF: 4.09)

Xu WT, Bian ZY, Fan QM, Li G, Tang TT.  Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Letters, 2009; 281: 32-41. (IF: 3.54)

Rapid expansion of bone marrow derived mesenchymal stem cells (MSCs) using rotary bioreactor.  Ni M, Xie HQ, Chan F, Yang ZM, Qin L, Li G.  Journal of Medical Biomechanics, 2009; 24(1): 66-71.

Zhao L, Li G, Zhou GQ. SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation. Journal of Bone and Mineral Research, 2009; 24 (5): 826-836.  (IF: 6.04)

Bian ZY, Gan YK, Hao YQ, Xu WT, Li G, Tang TT. Increased number of mesenchymal stem cell-like cells in peripheral blood of patients with bone sarcomas. Archives of Medical Research, 2009; 40(3):163-8. (IF:1.88)

Tang PF, Li G, Huang P, Wang Y. Development, characterization and validation of porous carbonated hydroxyapatite bone cement. Journal of Biomedical Material Research Part B: Applied Biomaterials,  2009; 90(2):886-93. (IF: 2.51)

Hanratty BM, Raby JT, Tang PF, LI G.  Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model. Journal of Orthopaedic Research and Surgery, 2009, 4: 1.

Zhao L, Li G, KM Chan, Wang Y, Tang PF.  Comparison of multipotent differentiation potentials of primary bone marrow stromal cells and the mesenchymal stem cell line C3H10T1/2.  Calcified Tissue International, 2009; 84:56-64. (IF: 2.32)

Tang PF, Burke G, Li G, Wang Y. Patients with long bone fracture have altered Caveolin-1 expression in their peripheral blood mononuclear cells. Archives of Orthopaedic and Trauma Surgery, 2009; 129(9):1287-92. (IF:1.12)

Wang Y, Ni M, Tang PF, Li G. Novel application of HA-TCP biomaterials in distraction osteogenesis shortened the lengthening time and promoted bone consolidation. Journal of Orthopaedic Research, 2009; 27:477-482. (IF: 3.11)

2008-1998  
  段王平, 張民,李剛,衛小春. 骨形態發生蛋白複合HA/TCP修復去勢大鼠骨缺損的研究. Experimental studies on HA/TCP with rhBMP-2 for bone defect repair in osteoporotic rats中國骨質疏鬆雜誌, Chinese Journal of Osteoporosis 2008; 14(9): 150-156.

 何君仁, 楊自權, 李剛, 衛小春. 脫細胞軟骨生物支架材料與大鼠骨髓間充質幹細胞共培養及體內埋植後的降解. 中國組織工程研究與臨床康復, 2008; 12(27): 5230-5234.

何君仁, 楊自權, 李剛, 李鵬翠,丁娟, 衛小春. 脫細胞軟骨生物支架材料的生物學特性. 生物骨科材料與臨床研究ORTHOPAEDIC BIOMECHANICS MATERIALS AND CLINTCAL STUDY, 2008 年5卷4期.

Yang ZQ, He JR, Li G, Yang SH, Wei XC.  Research on preparation and characters of decellularized cartilage matrix for tissue engineering.  Chinese Journal of Reparative and Reconstructive Surgery, 2008; 22(10):98-103.

Wang Y, Wan C, Szőke G, Ryaby JT, Li G.  Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles enhanced bone formation during distraction osteogenesis.  Journal of Orthopaedic Research, 2008; 26: 539-546. (IF:3.11)

LI G, Tang PF. Update distraction osteogenesis/histogenesis. Journal of Japanese Pediatric Orthopaedic Association, 2008; 17 (2): 381-289.

Bhatwadekar AD, Glenn JV, Li G, Curtis TM, Gardiner TA, Stitt AW. Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy. Investigation Ophthalmology Vision Science; 2008; 49(3):1232-41. (IF:3.43)

Amir LR, Li G, Schoenmaker T, Everts V, Bronckers AL. Effect of thrombin peptide 508 (TP508) on bone healing during distraction osteogenesis in rabbit tibia. Cell Tissue Research; 2007; 330: 35-44. (IF: 2.31)

Wang Y, Chen X, Armstrong M, Li G. Survival of bone marrow-derived mesenchymal stem cells in a xenotransplantation model.  Journal of Orthopaedic Research; 2007; 25: 926-932. (IF: 3.11)

Chen X, McClurg A, Zhou GQ, McCaiguea M, Armstrong MA, Li G. Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules. Stem Cells; 2007; 25:364-370. (IF:7.75)

He Q, Wan C, Li G. Concise review: multipotent mesenchymal stromal cells in blood. Stem Cells; 2007; 25:69-77. (IF: 7.75)

Murnaghan M, Li G, Marsh DR. Nonsteroidal anti-inflammatory drug-induced fracture nonunion: An inhibition of angiogenesis?  Journal of Bone and Joint Surgery (American Volume); 2006; 88:140-147. (IF: 2.14)

Chen X, Armstrong, MA, Li G. Mesenchymal stem cells in immunoregulation. Immunology and Cell Biology, 2006; 84(5): 413-421. (IF: 4.2)

Chen X, Xu H, Wan C, McCaigue M, Li G.  Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells (MSCs).  Stem Cells; 2006; 24: 2052-2059. (IF: 7.75)

Wan C, He Q, Li G.  Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone defect model.  Journal of Orthopaedic Research; 2006; 24(4):610-8. (IF:3.11)

Mushipe MT, Chen X, Jennings D, Li G. Seeded cells survive impaction grafting technique: allograft substitute for revision arthroplasty?  Journal of Orthopaedic Research; 2006; 24(3):501-7. (IF: 3.11)

Wan C, He Q, Li G. Osteoclastogenesis in the nonadherent cell population of human bone marrow is inhibited by rhBMP-2 alone or together with rhVEGF.  Journal of Orthopaedic Research; 2006; 24(1): 29-36. (IF: 2.77)

Wan C, He Q, McCaige M, Marsh D, Li G.  Nonadherent cell population of human marrow culture is a complementary source of mesenchymal stem cells (MSCs). Journal of Orthopaedic Research; 2006; 24 (1): 21-28. (IF: 2.77)

Li G, Qin SH. New developments in distraction osteogenesis: from basic research to clinical applications.  China Journal of Surgery, 2005; 43(8): 540-543.

Shirley D, Marsh D, Jordan G, McQuaid S, Li G.  Systemic recruitment of osteoblastic cells in fracture healing.  Journal of Orthopaedic Research, 2005; 23 (5): 1013-21. (IF: 2.77)

Li G, Cui Y, McIlmurray L, Allen WE, Wang H.  rhBMP-2, rhVEGF165, rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells. Journal of Orthopaedic Research, 2005; 23 (3): 680-685. (IF: 2.77)

Li G, Bunn J, Mushipe MT, He Q, Chen X.  Effects of over-expression pleiotrophin (PTN) on mouse long bone development, fracture healing and bone repair.  Calcified Tissue International, 2005; 76(4):299-306. (IF: 2.32)

Murnaghan M, Mcilmurray L, Mushipe M, Li G. Time for treating bone fracture using rhBMP-2: A randomised placebo controlled mouse fracture trial.  Journal of Orthopaedic Research, 2005; 23 (3): 625-631. (IF: 2.77)

Li G, Ryaby JT, Carney DH, Wang H.  Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis.  Journal of Orthopaedic Research, 2005; 23 (1): 196-202. (IF: 2.77)

Zheng W, Xie Y, Li G, Kong J, Liu W, Feng JQ, Li YC.  Critical role of calbindin-D28K in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28K.  Journal of Biological Chemistry, 2004; 279(50): 52406-13. (IF: 5.33)

Li G.  New developments and insights learned from distraction osteogenesis.  Current Opinion in Orthopaedics, 2004; 15: 325-330. (IF: 0.66)

Bunn JR, Canning J, Burke G, Mushipe M, Marsh DR, Li G. Production of consistent crush lesions in murine quadriceps muscle - A biomechanical, histomorphological and immunohistochemical study. Journal of Orthopaedic Research, 2004; 22: 1336-1344. (IF: 2.77)

Connolly CK, Li G, Bunn J, Mushipe M, Dickson G, Marsh D.  A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals. Journal of Orthopaedic Research, 2003; 21: 843-849. (IF: 2.77)

Li G, Dickson G, Marsh D, H Simpson. Rapid new bone tissue remodeling during distraction osteogenesis is associated with apoptosis. Journal of Orthopaedic Research, 2003; 21:28-35. (IF: 2.77)

Li G, Bouxsein ML, Luppen C, Li XJ, Wood M, Seeherman HJ, Wozney JM, Simpson H. Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis. Journal of Orthopaedic Research, 2002, 20: 779-788. (IF: 2.77)

Li G, White G, Connolly C, Marsh D.  Cell proliferation and apoptosis during fracture healing.   Journal of Bone and Mineral Research, 2002; 17: 791-799. (IF: 6.02)

Lacroix D, Prendergast PJ, Li G, Marsh D.  Biomechanical model to stimulate tissue differentiation and bone regeneration: application to fracture healing. Medical & Biological Engineering & Computing, 2002; 40: 14-21. (IF: 1.78)

Li G, Virdi A, Ashhurst DE, Simpson AHRW and Triffitt JT.  Tissues formed during distraction osteogenesis in the rabbit are determined by distraction rate: localization of the cells that express mRNAs and the distribution of types I and II collagens.  Cell Biology International, 2000; 24(1): 25-33. (IF: 1.8)

Li G, Simpson AHRW, Kenwright J, Triffitt JT. Effect of lengthening rate on angiogenesis during distraction osteogenesis.  Journal of Orthopaedic Research, 1999; 17(3): 362-367. (IF: 2.77)

Li G, Simpson AHRW, Triffitt JT. The role of chondrocytes in intramembranous and endochondral ossification during distraction osteogenesis in the rabbit.  Calcified Tissue International, 1999; 64: 310-317. (IF: 2.32)

Li G, Berven S, Athanaou NA, Simpson AHRW. Bone transport over an intramedullary nail : A case report with histologic examination of the regenerate.  Injury, 1999; 30(8):525-34. (IF: 2.38)

Marsh D, Li G.  The biology of fracture healing: optimizing the outcome.  British Medical Bulletin, 1999; 55(4), 856-869. (IF: 2.9)

DeCoster TA, Simpson AHRW, Wood M, Li G, Kenwright J. Biologic model of bone transport distraction osteogenesis and vascular response.  Journal of Orthopaedic Research, 1999; 17(2): 238-45. (IF: 2.77)

Li G, Berven S, Simpson AHRW, Triffitt JT. Expression of BMP-4 mRNA during distraction osteogenesis.  Acta Orthopaedica Scandinavica, 1998; 69(4): 420 -425. (IF:1.05)

Before 1998  
 

Li G, Simpson AHRW, Kenwright J, Triffitt JT. Assessment of cell proliferation in regenerating bone during distraction osteogenesis at different distraction rates.  Journal of Orthopaedic Research, 1997; 15(5): 765 -772. (IF:2.77)

Li G, Simpson, AHRW, Kenwright J, Triffitt JT.  Cell Proliferation as assessed by expression of proliferating cell nuclear antigen or the uptake of bromodeoxyuridine in a rabbit model of leg-lengthening.  Veterinary and Comparative Orthopaedic and Traumatology (V.C.O.T), 1996; 9: 95-100. (IF:0.93)

Teng Q, Zhang B, Ma C, Li G, Zhu X. Experimental study of fat embolism syndrome.  Chinese Medical Journal (English). 1995; 108(8): 595-600. (IF:0.8)

Teng Q, Li G, Zhang B, Zhu X, Ma C. Experimental study of early diagnosis and treatment of fat embolism syndrome.  Journal of Orthopaedic Trauma, 1995; 9(3): 183-189. (IF: 1.78)

Li G. Morbidity and clinical indications of anemia in elderly people. Chinese Journal of Foreign Medicine. 1990; (3): 127-129.

Li G. The function of epidermal growth factor (EGF) in stomach protection and ulcer healing.  Chinese Journal of Foreign Medicine and Pharmacy. 1989; (4): 205-207.

BOOKS EDITED (CLICK HERE FOR THE LINK)

  Ilizarov 技術骨科應用進展。 秦泗河,李剛主編。 人民軍醫出版社, 北京, 2014.1 (ISBN 978-7-5091-7054-4) (120 万字)  Development and application of Ilizarov technology in orthopaedic surgery.  Qin Sihe and Li Gang (Editor). People’s Military Medical Press, Beijing, 2014. 01 (ISBN 978-7-5091-7054-4); 120K words
  實用骨外固定學。 夏和桃主編。 彭愛民, 劉利民,李剛, 秦泗河副主編。 人民衛生出版社, 北京, 2013 (ISBN 978-7-117-17408-4) (202萬字) Practical Guides for Bone External Technology.  Xia He-Tao (Editor). Peng Ai-Min, Liu Li-Min; Li Gang and Qin Si-He (Associate Editor). People’s Medical Publishing House, Beijing, PR China, 2013 (ISBN 978-7-117-17408-4), 202K words.

BOOK CHAPTERS

  Qi XJ, Bell PR, Li G.  “Bone morphogenetic proteins in bone formation and development”  In Deng HW and Liu YZ (ed) Current Topics in Bone Biology, pp 163-177.  World Scientific Publisher, Singapore, 2005. [English Version] [Chinese Version]
  Wan C and Li G.  “Bone marrow adipogenesis in osteoporosis” In Deng HW and Liu YZ (ed) Current Topics in osteoporosis, pp178-201.  World Scientific Publisher, Singapore, 2005.[English Version] [Chinese Version]
  Connolly M, Li G.  “Skeletal stem cells”  In Deng HW and Liu YZ (ed) Current Topics in Bone Biology, pp57-71.  World Scientific Publisher, Singapore, 2005. [English Version] [Chinese Version]
  King E, Li G. “The social and financial costs of osteoporosis”  In Deng HW and Liu YZ (ed) Current Topics in Osteoporosis, pp17-26. WorldScientific Publisher, Singapore, 2005. [English Version] [Chinese Version]
  Li G and Murnaghan M. “Monitoring fracture healing using digital radiographies”  In Qin L, Genant HK, et al (ed) Advanced Bioimaging Technologies in Assessment of Quality of Bone and Scaffold Biomaterials, pp 543-552.  Springer, Berlin, 2007.
  Zhang T and Li G. “Use of bone marrow mesenchymal stem cells as tumor specific delivery vehicles”  pp 191-201. In M.A. Hayat (ed.), Stem Cells and Cancer Stem Cells, Volume 9, 191 © Springer Science + Business Media, Dordrecht 2013.
 

李剛. “肢體再生的生物學基礎與進展” pp 20-37. 實用骨外固定學。 夏和桃主編。 人民衛生出版社,北京,2013 (ISBN 978-7-117-17408-4).

 

李剛. “肢體再生的生物學基礎再生醫學” pp 33-46. Ilizarov 技術骨科應用進展。 秦泗河,李剛主編。 人民軍醫出版社,北京,2014.1 (ISBN 978-7-5091-7054-4).

 

李剛. “夢裡尋他千百度-李剛與Ilizarov技術的情緣” pp 592-598. Ilizarov 技術骨科應用進展。 秦泗河,李剛主編。 人民軍醫出版社,北京,2014.1 (ISBN 978-7-5091-7054-4).

 

李楠,王魁星, 李剛。 “間充質幹細胞技術與骨科應用” pp194-206。 骨內科學。秦嶺 主編。 人民衛生出版社, 北京, 2013 (ISBN 978-7-117-18088-7).

  张涛,王喜良,李刚。“肢体再生的生物学基础和再生医学” pp 185-191。干细胞与再生医学习题集。庞希宁, 付小兵。人民衛生出版社,北京,2015 (ISBN 978-7-117-20957-1/ R.20958).

KNOWLEDGE TRANSFER ACTIVITIES

PATENTS

(CLICK HERE FOR DETAILS)
 

骨科外固定模擬矯形分析儀。夏和桃, 唐佩福, 王坤正, 李剛, 夏洪箐。 中國發明專利ZL 2009 1 0307851.X。授權證書號737564.

組合式多功能截骨器。唐佩福, 王坤正,唐海, 李剛, 夏和桃,彭愛民, 楊華清。中國實用新型專利號 ZL 2010 2 0589056.2. 授權證書號1792731.

Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene.  Li Gang, Li Yak Wai, Lau Po Ying.  US Provisional patent application filed March 2012 (CHUK Reference: 11/MED/4514).

間充質幹細胞表達自殺基因用來抗腫瘤的治療.  Li Gang, Li Yak Wai, Lau Po Ying.  中國發明專利filed March 2012 (CHUK Reference: 11/MED/4514).

踝关节冠状面畸形调控矫形器。夏和桃,李剛,彭爱民,王坤正, 唐海, 夏洪箐。中國發明專利ZL 2013 1 0400836.6。授權證書號1685211.

踝关节多维调控矫形器。夏和桃,李剛,彭爱民,夏洪箐, 刘利民。中國發明專利ZL 2013 1 0400817.3。授權證書號1684956.

肘关节动静结合调控外固定器。夏和桃,李剛,彭爱民,夏洪箐,刘利民。中國發明專利ZL 2013 1 0400954.7。授權證書號1661159.

膝关节动静结合调控外固定器。夏和桃,李剛,彭爱民,夏洪箐,杨华清,刘利民。中國發明專利ZL 2013 1 0400953.2。授權證書號1660045.

快速牵伸延长杆。夏和桃,李剛,唐佩福,彭爱民,王坤正,夏洪箐。中國發明專利ZL 2013 1 0400851.0。授權證書號1660706.

肩关节动静结合调控外固定器。夏和桃,李剛,彭爱民,唐佩福,刘利民,夏洪箐。中國發明專利ZL 2013 1 0400834.7。授權證書號1659033.

肱骨近端T型外固定器。夏和桃,唐海, 唐佩福,彭爱民,李剛,杨华清,夏洪箐。中國發明專利ZL 2013 1 0400794.6。授權證書號1684697.

马蹄足矫形器。夏和桃,李剛,唐海,彭爱民,夏洪箐,刘利民。中國發明專利ZL 2013 1 0400853.X。授權證書號1659597.

管状牵伸加压连接杆控制装置及骨外固定器。夏和桃,李剛,唐海,彭爱民,夏洪箐,刘利民。中國發明專利ZL 2013 1 0400810.1。授權證書號1659055.

髋关节矫形与股骨延长器。夏和桃,李剛,彭爱民,刘利民,王坤正,夏洪箐。中國發明專利ZL 2013 1 0400852.5。授權證書號1659311.

跟足多功能调控外固定器。夏和桃,李剛,彭爱民,夏洪箐,刘利民,杨华清。中國發明專利ZL 2013 1 0400828.1。授權證書號1660513.

踝关节冠状面复合畸形调控矫形器。夏和桃,李剛,彭爱民,唐佩福,夏洪箐,刘利民。中國發明專利ZL 2013 1 0400826.2。授權證書號168833.

   
 
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