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CONTACT INFORMATION
Office : (852) 3505-1559
Email : louischeung@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Undergraduate teaching:
MBChB Programme
BEng in Biomedical Engineering
Postgraduate supervision:
MPhil/PhD in Orthopaedics & Traumatology
MSc in Musculoskeletal Medicine, Rehabilitation and Geriatric Orthopaedics
MSc in Biomedical Engineering
ORCID: 0000-0003-3247-8255
ResearcherID: J-2150-2018 |
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Professor CHEUNG Wing-hoi, Louis 張穎愷 |
BSc(Hons), PhD, PgCert(Biostatistics)
Professor
教授
Graduate Division Head
研究生部主任
Director of Musculoskeletal Research Laboratory
骨關節肌肉研究實驗室主任
Deputy Director of MSc in Musculoskeletal Medicine, Rehabilitation and Geriatric Orthopaedics Programmes
骨關節醫學、康復及老年骨科理學碩士課程副主任
Academic Appointment: Chairperson, Animal Experimentation Ethics Committee, CUHK
學術委任: 香港中文大學動物實驗倫理委員會主席
BIOGRAPHY
Professor Cheung graduated with a PhD from the Department of Orthopaedics & Traumatology at CUHK in 2000 and joined the academic staff in 2005. He is currently a Professor and Director of the Musculoskeletal Research Laboratory in the Department of O&T at CUHK. Additionally, he serves as an Investigator at the Musculoskeletal Ageing Laboratory, Li Ka Shing Institute of Health Sciences, CUHK. His research interests include fracture healing, osteoporotic fractures, sarcopenia, and mechanical stimulation. He also serves as a researcher at the Hong Kong-Shenzhen Innovation and Technology Research Institute (FITRI) and the CUHK Shenzhen Research Institute.
Prof. Cheung's research primarily focuses on understanding and improving osteoporotic fracture healing and sarcopenia, as well as the effects of mechanical stimulation on bone & muscle health. His work on low-magnitude high-frequency vibration (LMHFV) treatment has been particularly influential, demonstrating its potential to enhance fracture healing and mitigate the effects of sarcopenia. This innovative approach has been successfully translated into a non-invasive treatment aimed at improving musculoskeletal health, especially in the elderly population, and has been recommended by the Centers for Disease Control and Prevention, USA.
He is a member of the editorial boards of several international journals and an ad hoc reviewer for over 50+ professional journals. He also serves as a reviewer for the AO Foundation and several European Research Grant Councils. Prof. Cheung is a committee member of ISFR and FFN-HKSAR, an active member of ORS and a lifetime member of ICMRS. He has published 170 peer-reviewed international articles, 11 book chapters, and over 390 conference abstracts, and has contributed as an editor for one book. He has received 30+ research awards, including the Berton Rahn Research Fund of the AO Foundation in 2013, the Healthstar Osteoporosis Medical-Research Award (HOMA) in 2020, and a Gold Medal at the International Exhibition of Inventions Geneva in 2024. He also holds 7 patents (1 PCT, 3 US, 2 China, 1 UK).
SPECIALISED RESEARCH AREAS
- Osteoporotic Fracture Healing and Sarcopenia
- Mechanical Stimulation
- Biophysical Intervention
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SELECTED PUBLICATION
| 1. |
Bao Z, Cui C, Liu C, Long Y, Wong RMY, Chai S, Qin L, Rubin C, Yip BHK, Xu Z, Jiang Q, Chow SKH, Cheung WH*. Prevention of age-related neuromuscular junction degeneration in sarcopenia by low-magnitude high-frequency vibration. Aging Cell. 23(7):e14156, 2024. (IF=8.0) |
| 2. |
Long YF, Chow SK, Cui C, Wong RMY, Zhang N, Qin L, Law SW, Cheung WH*. Does exercise influence skeletal muscle by modulating mitochondrial functions via regulating MicroRNAs? A systematic review. Ageing Res Rev. 91:102048, 2023. (IF=13.10) |
| 3. |
Cui C, Bao Z, Chow SKH, Wong RMY, Welch A, Qin L, Cheung WH*. Magnesium supplementation and low-magnitude high-frequency vibration attenuate sarcopenic muscle through PI3K/Akt/mTOR pathway. Int J Mol Sci. 23(21):12944, 2022. (IF=5.60) |
| 4. |
Long YF, Chow SKH, Cui C, RMY Wong, Qin L, Law SW, Cheung WH*. Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: a systematic review. J Orthop Translat. 35:37-52, 2022. (IF=6.60) |
| 5. |
Cheung WH*, Hung VWY, Cheuk KY, Chau WW, Tsoi KKF, Wong RMY, Chow SKH, Lam TP, Yung PSH, Law SW, Qin L. Best performance parameters of HR-pQCT to predict fragility fracture – systematic review and meta-analysis. J Bone Miner Res. 36(12):2381-2398, 2021. (IF=6.20) |
| 6. |
Cheng KYK, Chow SKH, Hung VWY, Wong CHW, Wong RMY, Tsang CSL, Kwok T, Cheung WH*. Diagnosis of sarcopenia by evaluating skeletal muscle mass by adjusted bioimpedance analysis (BIA) validated with DXA. J Cachexia Sarcopenia Muscle. 21(6):2163-2173, 2021. (IF=8.90) |
| 7. |
Liu C, Cheung WH*, Li J, Chow SKH, Yu J, Wong SH, Ip M, Sung JJY, Wong RMY. Understanding the gut microbiota and sarcopenia: a systematic review. J Cachexia Sarcopenia Muscle. 12(6):1393-1407, 2021. (IF=8.90) |
| 8. |
Chui CS, Leung KS, Qin JH, Shi DF, Augat P, Wong RMY, Chow SKH, Huang XY, Chen CY, Lai YX, Yung PSH, Qin L, Cheung WH*. Population-based and personalized design of total knee replacement prosthesis for additive manufacturing based on Chinese anthropometric data. Engineering. 7(3):386-94, 2021. (IF=12.80) |
| 9. |
Wang J, Cui C, Chim YN, Yao H, Shi L, Xu J, Wang J, Wong RMY, Leung KS, Chow SKH, Cheung WH*. Vibration and HMB suppresses intramuscular fat infiltration and adipogenic differentiation in sarcopenic mice. J Cachexia Sarcopenia Muscle. 11:564-77, 2020. (IF=8.90) |
| 10. |
Qin JH, Chow SK, Guo AY, Wong WN, Leung KS, Cheung WH*. Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transection induced osteoarthritis rat model. Osteoarthritis Cartilage. 27(7):1061-7, 2014. (IF=7.00) |
SELECTED AWARDS
| 1. |
學科成就獎: 第十屆中國藥學發展獎康辰骨質疏鬆醫藥研究獎 (HOMA), 2020 |
| 2. |
壹等獎： 通用型骨科導航手術機器人系統關鍵技術研發與臨床應用。北京市科學技術獎, 2018 |
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Shihao Liu-Xianyi Zhu Memorial Best Paper Award: Activated osteocytes and enhanced mineralization in osteoporotic metaphyseal fracture healing model augmented with cyclic mechanical loading. 9th International Conference on Osteoporosis and Bone Research. Suzhou, China. 2018 |
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Best Paper Award for Associate Member: Influence of sarcopenia on osteoporotic fracture healing in senescence accelerated mouse model. The 36th Annual Congress of Hong Kong Orthopaedic Association. Hong Kong. 2016 |
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Berton Rahn Research Fund Prize Award: AO Foundation, Switzerland. Lima, Peru. 2013 |
RESEARCH TRANSLATION
| 1. |
Low-magnitude high-frequency vibration therapy [licensed for commercialization] - a CDC recommended fall intervention (2023 CDC compendium of Effective Fall Interventions: What Works for Community-Dwelling Older Adults, 4th Edition; https://www.cdc.gov/falls/interventions/falls-compendium.html, page 94-95)
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