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CONTACT INFORMATION
Office : (852) 3763-6111
Email : twxleo@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology
ORCID: 0000-0003-3462-2740
Scopus Author ID: 55192227700
Google Scholar: QTfiyYEAAAAJ |
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Dr. TONG Wenxue 童文學 |
BSc (SDNU), Master of Cell Biology (SJTU), PhD (CUHK)
Research Assistant Professor
研究助理教授
BIOGRAPHY
Dr. Tong obtained his BSc degree from the College of Life Sciences, Shandong Normal University (SDNU) in 2009. He continued his study at Shanghai Jiao Tong University (SJTU) School of Medicine to research the role of articular cartilage stem cells in osteoarthritis and obtained his master’s degree in cell biology in 2012. He graduated from the Department of Orthopaedics and Traumatology in 2017 by investigating the role of Wnt16 in skeletal development and osteoarthritis pathology and continued the postdoctoral training in the Department of Orthopaedics and Traumatology of CUHK.
Dr. Tong focused on gene function, gene therapy, and biodegradable materials, especially Mg-based implant studies. Dr. Tong has achieved many academic accomplishments, including a total of 26 publications with an H-Index 13, with a research article as the first author from his Ph.D. thesis published in Annals of the Rheumatic Diseases (IF=27.973). Dr. Tong has obtained a Health and Medical Research Fund (HMRF) as a PI and Impact Postdoctoral Fellow Scheme (IPDFS), and several Direct Grants as PI or Co-PI. Dr. Tong also serves as a core member or coordinator to assist in drafting several research grants, such as the Theme-based Research Scheme (TRS), Areas of Excellence Scheme (AoE), Research Impact Fund (RIF), Passion for Perfection, NSFC-RGC, MHKJFS (ITF), etc. Dr. Tong also established a start-up company, Targene Biotech (Hong Kong) Limited, as the Chief Executive Officer (CEO) in 2019 to push forward the gene therapy research translation and obtained the support of the Technology Start-up Support Scheme for Universities (TSSSU).
EXPERTISE
- Osteoarthritis Pathology and Cartilage Regeneration
- Gene Therapy
- Mg-based Biomaterial R&D and Translational Research
SPECIALISED RESEARCH AREAS
- Gene Function in Musculoskeletal Development and Disease Pathology
- Gene Therapy Using Tissue Targeting Adeno-associated Virus
- Biomaterial R&D and Translation
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SELECTED PUBLICATION
| 1. |
Shunxiang Xu#, Hongwei Shao#, Zheyu Jin, Jiankun Xu, Fanyan Deng, Yuantao Zhang, Liangbin Zhou, Samuel Ka-kin Ling, Congqin Ning*, Wenxue Tong*, Ling Qin*. Magnesium silicate composite patch with neurovascular regenerative properties promotes diabetic wound healing in mice. Interdisciplinary Materials, 29 July 2025. (IF=31.6) |
| 2. |
Shao H, Xu S, Zeng F, Jin Z, Shan Z, Kang J, Tian Q, Mao Z, Zhang Y, Xu J, Tong W*, Qin L*. Metal–Organic Framework-Integrated Nanoplatform Orchestrates Osteochondral-Synovial Homeostasis for Osteoarthritis Therapy. ACS Nano. 2025 Sep 1 (IF=16) |
| 3. |
Qing Lu, Yu-Sheng Hsueh, Wenxue Tong, Yuantao Zhang, Jiankun Xu, Ling Qin. Importance to understand medical device regulations for accelerating clinical translation. Journal of Orthopaedic Translation. Volume 51, March 2025, Pages 290-297. (IF=7.8) |
| 4. |
Li C, Zhang W, Nie Y, Du X, Huang C, Li L, Long J, Wang X, Tong W, Qin L, Lai Y. Time-Sequential and Multi-Functional 3D Printed MgO2/PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment. Adv Mater. 2024 Aug;36(34):e2308875. (IF=27.4) |
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Yao Z#, Yuan W#, Xu J, Tong W, Mi J, Ho PC, Chow DHK, Li Y, Yao H, Li X, Xu S, Guo J, Zhu Q, Bian L*, Qin L*. Magnesium-Encapsulated Injectable Hydrogel and 3D-Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration. Advanced Science, 2022 Jul;9(21):e2202102. (IF=17.521) |
| 6. |
Tong W#, Zeng Y#, Chow D, Yeung W, Xu J, Deng Y, Ho K, Qin L*, Mak K*. Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade. Annals of the Rheumatic Diseases. 2019 Feb 11. (IF=27.973) |
| 7. |
Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, Ho K, Qin L, Song H*, Mak K*. Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation. Nature Communications. 2018 Nov 1;9(1):4564. (IF=17.694) |
| 8. |
Tong W, Mak K, Qin L*. Introducing Wnt16 attenuates the severity of osteoarthritis. Journal of Orthopaedic Translation. Volume 7, 2016 October, (IF=7.8) |
| 9. |
Tong W, Geng Y, Huang Y, Shi Y, Xiang S, Zhang N, Qin L, Shi Q, Chen Q, Dai K, Zhang X*. In Vivo Identification and Induction of Articular Cartilage Stem cells by Inhibiting NF-κB Signaling in osteoarthritis. Stem Cells. 2015 Oct;33(10):3125-37. doi: 10.1002/stem.2124. Epub 2015 Aug 25. (IF=5.845) |
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Shi Y#, Fu Y#, Tong W, Geng Y, Lui P, Tang T, Zhang X*, Dai K*. Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway. J Cellular Biochemistry. 2012 Oct; 113(10):3133-42. doi: 10.1002/jcb.24190. (IF=4.48) |
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