|
|
|
CONTACT INFORMATION
Office : (852) 3763-6057
Email : xiaonachen@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology
ORCID: 0000-0001-6241-811X
Scopus Author ID: 24170717900
Google Scholar: tqPruWsAAAAJ |
|
Dr. CHEN Xiaona 陳小娜 |
BSc (ECNU), MSc (ECNU), PhD (CUHK)
Research Assistant Professor
研究助理教授
BIOGRAPHY
Dr. Chen obtained her BSc degree from the School of Life Sciences, East China Normal University (ECNU) in 2006. She continued her study at ECNU, focusing on miRNAs and cancer, and obtained her MSc degree in 2009. She switched to lncRNAs and skeletal muscle related research and obtained her PhD degree in Obstetrics and Gynaecology from the Chinese University of Hong Kong (CUHK) in 2014. She pursued her postdoctoral training in the Department of Orthopaedics and Traumatology of CUHK (2015-2019) and in the Division of Life Science at the Hong Kong University of Science and Technology (2019-2022).
Her research focuses on deciphering the regulatory mechanisms of long non-coding RNA, RNA binding proteins, G-quadruplexes (G4) and helicase proteins in modulating gene expression in skeletal muscle stem cells (also known as muscle satellite cells, SC) during muscle regeneration and aging.
SPECIALISED RESEARCH AREAS
- Gene Regulation in Skeletal Muscle Stem Cells, Muscle Regeneration and Aging
- Biological Regulatory Functions of DNA/RNA G-quadruplexes
- Gene Regulatory Functions of Helicase Proteins
|
SELECTED PUBLICATION
| 1. |
Chen X*#, Yang F*, Zhang S*, Guo X, Zhao J, Qiao Y, He L, Li Y, Zhou Q, Ong MT, Kwok CK, Sun Hao#, Wang H#. DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights. Genome Biology. 2025 Sep 5;26(1):269. (*Co-first authors and #co-corresponding authors) |
| 2. |
Zhang K, Nie Q, Li M, Chen X, Zhong L, Dai T, Guo X, Zhao H, Lau TC, Wang H, Chen SB, Kwok CK. RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. Nucleic Acids Research. 2025 Jan 24;53(3):gkaf039. doi: 10.1093/nar/gkaf039. |
| 3. |
Sun Q, Zhou Q, Qiao Y, Chen X, Sun H, Wang H. Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization. Nucleic Acids Research. 2025 Jan 7;53(1):gkae1271. doi: 10.1093/nar/gkae1271. |
| 4. |
Zhang Y, Zhao J, Chen X, Qiao Y, Kang J, Guo X, Yang F, Lyu K, Ding Y, Zhao Y, Sun H, Kwok CK, Wang H. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nature Communications. 2024 Nov 15;15(1):9890. doi: 10.1038/s41467-024-54000-y. |
| 5. |
He Z, Chen X, Liu G, Li Y, Yang F, Sun H, Wang H. Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging. Life Med. 2023 Nov 2;2(4):lnad039. doi: 10.1093/lifemedi/lnad039. eCollection 2023 Aug. |
| 6. |
Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, Xue Y, Sun H, Wang H. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. Elife. 2023 Mar 9;12:e82703. |
| 7. |
Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H, Wang H. Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging. Science Advances. 2023 Feb 17;9(7):eabo1360. |
| 8. |
Chen X*, Xue G*, Zhao J, Zhang Y, Zhang S, Wang W, Li Y, Yuan J, He L, Chan CY, Liu Y, Chen W, Zhao Y, Hu P, Sun H, Kwok CK, Wang H. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation. Cell Reports. 2022 Jun 7;39(10):110927. (* Co-first authors) |
| 9. |
Chen X*, Yuan J*, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar M, Isern J, Zhao Y, He L, Li Y, Mann C, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nature Communications. 2021 Aug 19;12(1):5043. (* Co-first authors) |
| 10. |
Chen X, He L, Zhao Y, Li Y, Zhang S, Sun K, So K, Chen F, Zhou L, Lu L, Wang L, Zhu X, Bao X, Esteban MA, Nakagawa S, Prasanth KV, Wu Z, Sun H, Wang H. Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discovery. 2017 Mar 14;3:17002. IF: 14.3 |
|
