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CONTACT INFORMATION
Office : (852) 3505-2730
Email : paulinelui@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate supervision:
MPhil/PhD in Orthopaedics & Traumatology
ORCID: 0000-0003-2446-6203
Scopus Author ID: 7006091505
Google Scholar: YnHsBPAAAAAJ |
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Professor LUI Po-yee, Pauline 吕宝仪 |
Ph.D. in Biochemistry, PgDip in Clinical Trial Research Methodology, PgCert in Pharmacology and Pharmaceutical Management, Fellow (FHEA), Accredited Supplemental Instruction (SI) Supervisor
Associate Professor
副教授
BIOGRAPHY
Dr. Pauline Po-Yee Lui is a renowned researcher in the field of Orthopaedic Sports Medicine, particularly focusing on tendons and ligaments. Her research interests include tendon stem cells and their niches, tissue engineering and regenerative medicine, tendinopathy, anterior cruciate ligament reconstruction, tendon and ligament healing, and clinical research in orthopaedics. She has published over 90 peer-reviewed papers and is recognized as a leading scientist in tendon stem cell research, with many of her works extensively cited. Her H-index (Google Scholar) is 48.
Dr. Lui is internationally acclaimed for her contributions to tendon-derived stem cells (TDSCs) and tendinopathy. Her group has reported on the erroneous differentiation of TDSCs and the in situ localization of these cells in tendon tissues, laying the foundation for numerous studies on the etiopathogenesis of tendinopathy. Her team is actively investigating various stem cell-based therapies and pharmaceuticals for managing this condition, leading to the filing of two PCT applications. Additionally, they are exploring novel therapies to enhance graft healing in anterior cruciate ligament reconstruction, resulting in the development of a stem cell sheet and an acellular stem cell sheet, along with one U.S. patent, one Chinese patent, and one provisional U.S. patent. A clinical trial for one intervention derived from her basic science research is currently underway.
Dr. Lui has received numerous awards for her innovations and has secured substantial research funding, totaling HKD $154.4 million from various organizations, including the University Grant Council, Innovation and Technology Committee, Food and Health Bureau, and The Hong Kong Jockey Club Charities Trust.
Due to her expertise in sports medicine, particularly in stem cells and regenerative medicine related to tendon and ligament injuries, she is frequently invited to review manuscripts and grant applications on these topics. She currently serves as a Grant Review Panel Member for Research Foundation Flanders (FWO) in Belgium and as a grant reviewer for the European Research Council, European Science Foundation, and the National Science Center of Poland. Additionally, she has been the reviewer for the Public Research Funding Scheme, Professional Services Advancement Support Scheme, and Monitoring and Evaluation Study of the Kwai Tsing District Health Centre for the Government.
Dr. Lui is also committed to community service, having served as an Institutional Review Board Member of CUHK/NTEC from 2011 to 2012. As a dedicated educator, she has supervised 10 Ph.D. students, 3 M.Phil. students, 25 M.Sc. students, and 35 undergraduates. She was the Deputy Co-Director of the M.Sc./Pg.D. program in Sports Medicine and Health Science from 2006 to 2013.
SPECIALISED RESEARCH AREAS
- Tendon Stem Cells and Their Niches
- Tissue Engineering and Regenerative Medicine
- Tendinopathy
- Anterior Cruciate Ligament Reconstruction
- Tendon and Ligament Healing
- Clinical Research in Orthopaedics
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SELECTED PUBLICATION
| 1. |
Lui PPY, Huang C, Zhang X. Selenium Nanoparticles Suppressed Oxidative Stress and Promoted Tenocyte Marker Expression in Tendon-Derived Stem/Progenitor Cells. Antioxidants (Basel). 2024;13(12):1536. |
| 2. |
Ling SK, Liang Z, Lui PPY. High-fat diet-induced obesity exacerbated collagenase-induced tendon injury with upregulation of interleukin-1beta and matrix metalloproteinase-1. Connect Tissue Res. 2024;65(6):447-457. |
| 3. |
Ma Z, Lee AYW, Kot CH, Yung PSH, Chen SC, Lui PPY. Upregulation of FABP4 induced inflammation in the pathogenesis of chronic tendinopathy. J Orthop Translat. 2024;47:105-115. |
| 4. |
Yao S, Liang Z, Lee YW, Yung PSH, Lui PPY. Bioactive Decellularized Tendon-Derived Stem Cell Sheet for Promoting Graft Healing After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2023;51(1):66-80. |
| 5. |
Lui PPY, Yung PSH. Inflammatory mechanisms linking obesity and tendinopathy. J Orthop Translat. 2021;31:80-90. |
| 6. |
Lui PPY, Wong OT, Lee YW. Transplantation of tendon-derived stem cells (TDSCs) pre-treated with connective tissue growth factor (CTGF) and ascorbic acid in vitro promoted better tendon repair in a patellar tendon window injury rat model. Cytotherapy. 2016; 18(1): 99-112. |
| 7. |
Lui PPY, Lee YW, Wong YM, Zhang X, Dai K, Rolf CG. Expression of Wnt pathway mediators in metaplastic tissue in animal model and clinical samples of tendinopathy. Rheumatology (Oxford) 2013;52(9):1609-1618. |
| 8. |
Rui YF, *Lui PPY, Wong YM, Tan Q, Chan KM. Altered fate of tendon-derived stem cells (TDSCs) isolated from a failed tendon healing animal model of tendinopathy. Stem Cells Dev 2013; 22(7): 1076-1085. |
| 9. |
Ni M, *Lui PPY, Rui YF, Lee YW, Lee YW, Tan Q, Wong YM, Kong SK, Lau PM, Li G, Chan KM. Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model. J Orthop Res 2012; 30(4): 613-619. |
| 10. |
Lui PP, Cheuk YC, Lee YW, Chan KM. Ectopic chondro-ossification and erroneous extracellular matrix deposition in a tendon window injury model. J Orthop Res 2012; 30(1): 37-46. |
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