|
|
|
CONTACT INFORMATION
Office : (852) 2471-6706
Email : waynelee@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate supervision:
MPhil/PhD in Orthopaedics & Traumatology
ORCID:
0000-0002-0486-360X
ResearcherID:
H-8298-2013 |
|
Professor LEE Yuk-wai, Wayne 李郁伟 |
BSc(Hons, HKBU), PhD(CUHK)
Assistant Professor
助理教授
BIOGRAPHY
Professor Wayne Lee obtained his PhD in Pharmacology from The Chinese University of Hong Kong (CUHK) in 2009 and subsequently pursued postdoctoral training in the Department of Orthopaedics and Traumatology at CUHK, focusing on cell therapy. He has published over 127 articles in peer-reviewed international journals (Scopus H-index 36), including 25 as a corresponding author in top-tier journals such as Arthritis & Rheumatology, Cell Death & Differentiation, Science Advances, EClinicalMedicine, Aging Cell, and Bioactive Materials. His research has received funding support from the GRF, HMRF, ITF, InnoHK, and the American Society for Bone and Mineral Research (ASBMR). Dr. Lee serves on the Youth Committee of the Journal of Orthopaedic Translation and as a reviewer for international journals and renowned research societies, including the Orthopaedic Research Society (ORS) and ASBMR. He is currently the Co-Director of the Joint Scoliosis Research Society of CUHK and Nanjing University. He has served as the Site Authorized Person of the ATP GMP Center at the Hong Kong Institute of Biotechnology from 2022 to 2025, assisting in obtaining the first local institution-led manufacturing license for ATP, and has released several CAR-T products for local clinical trials. His research focuses on three major areas of orthopaedics with significant clinical relevance: (a) Elucidating the mechanisms underlying disease progression in Adolescent Idiopathic Scoliosis (AIS) and developing novel prognostic models for curve prediction and personalized interventions. (b) Investigating the roles of understudied osteocytes in age-related musculoskeletal problems. (c) Developing GMP-compliant advanced cell therapy solutions for musculoskeletal disorders.
SPECIALISED RESEARCH AREAS
- Adolescent Idiopathic Scoliosis
- Clinical Application of Cell Therapy
- Musculoskeletal Aging
|
SELECTED PUBLICATION
| 1. |
R.L. Wang, B. Mehrjou, D. Dehghan-Banian, B.Y.S. Wang, Q.Q. Li, S. Deng, C. Liu, Z. Zhang, Y. Zhu, H. Wang, D. Li, X. Lu, J.C.Y. Cheng, M.T.Y. Ong, H.F. Chan, G. Li*, P.K. Chu*, W.Y.W. Lee*. Targeting long non-coding RNA H19 in Subchondral Bone Osteocytes Alleviates Cartilage Degradation in Osteoarthritis. Arthritis & Rheumatology, 2025;77(3):283-297
Featured in Clinical Connections of Arthritis & Rheumatology |
| 2. |
B.Y. Wang, A.W. Hsiao, H.T. Shiu, N. Wong, A.Y. Wang, C.W. Lee*, O.K. Lee*, W.Y.W. Lee*. Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway. Stem Cell Research & Therapy, 2023;14:195. |
| 3. |
K.G. Yang, E. Goff, K.L. Cheng, G.A. Kuhn, Y. Wang, J.C.Y. Cheng, Y. Qiu, R. Muller*, W.Y.W. Lee*. Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography. Bone, 2023;166:116594. |
| 4. |
K.K.W. Ho, W.Y.W. Lee*, J.F. Griffith, M.T.Y. Ong, G. Li. Randomized control trial of mesenchymal stem cells versus hyaluronic acid in patients with knee osteoarthritis – A Hong Kong pilot study. Journal of Orthopaedic Translation, 2022;37:69-77. |
| 5. |
Q. Li, R. Wang, Z. Zhang, H. Wang, X. Lu, J. Zhang, A. Kong, X.Y. Tian, H.F. Chan, A.C.K. Chung, J.C.Y. Cheng, Q. Jiang, W.Y.W. Lee*. Sirt3 mediates the benefits of exercise on bone in aged mice. Cell Death and Differentiation, 2023;30:152-167. |
| 6. |
J. Sun, J.H.T. Lo, L. Fan, T.L. Yiu, A. Shakoor, G. Li, W.Y.W. Lee*, D. Sun*. High-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration. Science Advances. 2022;8(33):eabp9245. |
| 7. |
B. Wang*, M. Pang, Y. Song, H. Wang, P. Qi, S. Bai, X. Lei, S. Wei, Z. Zong, S. Lin, X. Zhang, X. Cen, X. Wang, Y. Yang, Y. Li, Y. Wang, H. Xu, L. Huang, M. Tortorella, B. Cheng, W.Y.W. Lee*, D. Qin*, G. Li*. Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family. Bioengineering & Translational Medicine. 2022;e10354. |
| 8. |
Y. Wang, M. Li, C.O. Chan, G. Yang, J.C.K. Lam, B.C.S. Law, T.P. Lam, A.L.H. Hung, J.C.Y. Cheng, D.K.W. Mok*, W.Y.W. Lee*. Biological effect of dysregulated LBX1 on adolescent idiopathic scoliosis through modulating muscle carbohydrate metabolism. The Spine Journal. 2022;22(9):1551-1565. |
| 9. |
J. Zhang, K.Y. Cheuk, L. Xu, Y. Wang, Z. Feng, T. Sit, K.L. Cheng, E. Nepotchatykh, T.P. Lam, Z. Liu, A.L.H. Hung, Z. Zhu, A. Moreau, J.C.Y. Cheng, Y. Qiu, W.Y.W. Lee*, A validated composite model to predict risk of curve progression in adolescent idiopathic scoliosis. EClinicalMedicine, 2020;18:100236. |
| 10. |
H. Chen, J. Zhang, Y. Wang, K.Y. Cheuk, A.L.H. Hung, T.P. Lam, Y. Qiu, J.Q. Feng, W.Y.W. Lee*, J.C.Y. Cheng, Abnormal lacuno-canalicular network and negative correlation between serum osteocalcin and Cobb angle indicate abnormal osteocyte function in adolescent idiopathic scoliosis. FASEB Journal, 2019;33(12):13882-13892. |
|
