|
|
|
CONTACT INFORMATION
Office : (852) 3505-1559
Email : ningzhang@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Undergraduate teaching:
BEng in Biomedical Engineering
Postgraduate supervision:
MPhil/PhD in Orthopaedics & Traumatology
MSc in Musculoskeletal Medicine, Rehabilitation and Geriatric Orthopaedics
ORCID: 0000-0002-9513-9288
Scopus Author ID: 58743782400
Google Scholar: 3T5ykDIAAAAJ |
|
Professor ZHANG Ning 張宁 |
BSc (SDU), MSc (SJTU), PhD (CUHK)
Assistant Professor
助理教授
BIOGRAPHY
Professor Zhang is an Assistant Professor in the Department of Orthopaedics & Traumatology at the Chinese University of Hong Kong (CUHK). He received his PhD from CUHK and completed postdoctoral training in the Department of Orthopaedic Surgery at Stanford University.
Professor Zhang’s research focuses on the regeneration and rehabilitation of musculoskeletal disorders, including fragility fractures, large bone defects, and muscle and bone deterioration associated with aging or environmental stressors. His work integrates cell-based therapies, immunomodulation, tissue engineering, and biophysical interventions. He is deeply committed to identifying emerging risk factors through a multidisciplinary lens and developing novel therapeutic and rehabilitation strategies for musculoskeletal conditions.
Professor Zhang has authored over 70 peer-reviewed publications, and his research has been featured at numerous international conferences, earning recognition through invited talks, selections for new investigator awards, and podium spotlight sessions. He also serves as a guest editor and reviewer for several leading international journals.
EXPERTISE
- Genetic Modification
- Animal Models
- Cell-based Therapies
- Biophysical Intervention
- Mass Cytometry
SPECIALISED RESEARCH AREAS
- Immunomodulation for Bone and Muscle Regeneration
- Rehabilitation Interventions for Post-fracture Recovery
- Muscle-Bone Crosstalk
- Environmental Stressors and Musculoskeletal Health
|
SELECTED PUBLICATION
| 1. |
Zhang N*(co-corresponding), Yuan J, Li X, Su N, Wang Y, Chen S, Huang E, Gao Q, Yang F, Chow SKH, Goodman SB*. Single-cell RNA sequencing reveals early cell dynamics of MSC-based therapy in long bone critical-size defects in mice. J Orthop Translat. 55:121-31; 2025. |
| 2. |
Zhang N*(co-corresponding), Zhai L, Wong RMY, Cui C, Law SW, Chow SK, Goodman SB, Cheung WH*. Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches. Immun Ageing. 21(1):55; 2024. |
| 3. |
Li X, Shen H, Zhang M, Teissier V, Huang EE, Gao Q, Tsubosaka M, Toya M, Kushioka J, Maduka CV, Contag CH, Chow SK, Zhang N*(co-corresponding), Goodman SB*. Glycolytic reprogramming in macrophages and MSCs during inflammation. Front Immunol. 14:1199751; 2023. |
| 4. |
Huang EE, Zhang N 1 (co-first author), Ganio EA, Shen H, Li X, Ueno M, Utsunomiya T, Maruyama M, Gao Q, Su N, Yao Z, Yang F, Gaudillière B, Goodman SB. Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect. J Orthop Translat. 36:64-74. 2022. |
| 5. |
Hirata H, Zhang N 1 (co-first author), Ueno M, Barati D, Kushioka J, Shen H, Tsubosaka M, Toya M, Lin T, Huang E, Yao Z, Wu JY, Zwingenberger S, Yang F, Goodman SB. Ageing Attenuates Bone Healing by Mesenchymal Stem Cells in a Microribbon Hydrogel with a Murine Long Bone Critical-Size Defect Model. Immun Ageing. 19,14; 2022. |
| 6. |
Zhang N, Lo CW, Utsunomiya T, Maruyama M, Huang E, Rhee C, Gao Q, Yao Z, Goodman SB. PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regeneration. Stem Cell Res Ther. 12 (1), 1-11; 2021. |
| 7. |
Zhang N, Utsunomiya T, Lin T, Kohno Y, Ueno M, Maruyama M, Huang E, Rhee C, Yao Z, Goodman SB. Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice. Front Cell Dev Biol. 9:757830; 2021. |
| 8. |
Ueno M, Zhang N 1 (co-first author), Hirata H, Barati D, Utsunomiya T, Shen H, Lin T, Maruyama M, Huang E, Yao Z, Wu JY, Zwingenberger S, Yang F, Goodman SB. Sex Differences in Mesenchymal Stem Cell Therapy with Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model. Front Bioeng Biotechnol. 9: 755964; 2021. |
| 9. |
Utsunomiya T, Zhang N 1 (co-first author), Lin T, Kohno Y, Ueno M, Maruyama M, Rhee C, Huang E, Yao Z, Goodman SB.. Different effects of intramedullary injection of mesenchymal stem cells during the acute versus chronic inflammatory phase on bone healing in the murine continuous polyethylene particle infusion model. Front Cell Dev Biol. 9, 631063; 2021. |
| 10. |
Hu G, Zhang N 1 (co-first author), Li J, Wang J, Wu W, Li J, Tong W, Zhao X, Dai L, Zhang X.. TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling. Am J Pathol. 190(8):1701-1712; 2020. |
SELECTED AWARDS
| 1. |
Silver Medal. Artificial Intelligence Assisted Orthopaedic Prosthesis Design and Surgical Planning System. Silicon Valley International Invention Festival, Santa Clara, California, USA. 2024 |
| 2. |
Orthopaedic Basic Science Award. Does sarcopenia affect osteoporotic fracture healing? Myostatin as a target to enhance repair. The 40th Annual Congress of Hong Kong Orthopaedic Association. Hong Kong. 2020 |
| 3. |
Best Paper Award for Associate Member. Influence of sarcopenia on osteoporotic fracture healing in senescence accelerated mouse model. The 36th Annual Congress of Hong Kong Orthopaedic Association. Hong Kong. 2016 |
| 4. |
研究生國家獎學金. 中華人民共和國教育部, 2012 |
| 5. |
趙以甦骨科基礎獎優秀論文一等獎. TRAF3在IL-17引起的软骨破坏中作用研究. The 7th Annual Congress of Chinese Orthopaedic Association. Beijing, China. 2012. |
|
